I-distillation yamangqamuzanaubuchwepheshe obukhethekile bokuhlukanisa uketshezi nolwelwesi, obuhlukile kobucwebe bendabuko obuncike esimisweni sokuhlukanisa umehluko wamaphuzu abilayo. Lena inqubo yokukhishwa kwe-distillation kanye nokuhlanzwa kwempahla ezwela ukushisa noma amaphuzu aphezulu abilayo kusetshenziswa umehluko osendleleni yamahhala yokunyakaza kwama-molecule ngaphansi kwe-vacuum ephezulu. Ikakhulukazi esetshenziswa amakhemikhali, imithi, petrochemical, izinongo, amapulasitiki kanye namafutha kanye nezinye izimboni.
Izinto ezisetshenziswayo zidluliswa zisuka emkhunjini wokuphakela ziyiswe kumshini wokushunqisa ophuzwayo onejakhethi oyinhloko. Ngokuzungezisa kwerotha kanye nokushisisa okuqhubekayo, uketshezi olubonakalayo luyakhuhla lube yifilimu yoketshezi oluncane kakhulu, olunyakazayo, bese luphushwa phansi ngendlela ezungezayo. Ngenqubo yokwehla, okokusebenza okulula (okunephuzu eliphansi lokubilisa) oketshezini olubonakalayo kuqala ukuhwamuka, kudlulele ku-condenser yangaphakathi, futhi kube uketshezi olugeleza lwehlela esigabeni sokukhanya sokuthola flask. Izinto ezisindayo (njenge-chlorophyll, usawoti, ushukela, i-waxy, njll.) azihwamuki, kunalokho, zigeleza ngodonga lwangaphakathi lwe-evaporator lingene esigabeni esisindayo sokwamukela iflaski.