Emkhakheni we-biopharmaceuticals kanye nocwaningo lwesayensi, ukususwa kwezinyibilikisi kanye nokugxila kwezinto kuyizinyathelo ezibalulekile kuzo zombili izinqubo zokuhlola nezokukhiqiza. Izindlela zendabuko ezifana nokuhwamuka kanye ne-centrifugation ngokuvamile zihlushwa ukungasebenzi kahle, ukulahlekelwa izithako ezisebenzayo, nokukhishwa okungaphelele kwe-solvent. Izikomisi zokuqandisa zaselabhorethri, ezinezinzuzo ezihlukile zokushisa okuphansi nokucindezela okuphansi, ziye zavela njengamathuluzi aphumelela kakhulu kulezi zinqubo. Phakathi kwazo,"KOKUBILI" okomisa okomisazihamba phambili ekuthuthukiseni lobu buchwepheshe.
Isayensi Engemuva Kokomisa Iqhwa: Ukuphelelwa Ukushisa Kwezinga Eliphansi
A ilabhorethri yokumisa iqhwaifinyelela ukususwa kwe-solvent kanye nokugxila kwezinto ngezigaba ezintathu ezibalulekile:
Isiteji sokuqandisa ngaphambili:Izinto eziqukethe izincibilikisi ziqandiswa ngokushesha emazingeni okushisa asukela ku -40°C kuya ku -80°C, kwakheka amakristalu eqhwa aqinile.
Ukomisa Okuyisisekelo (I-Sublimation):Ngaphansi kwendawo ye-vacuum (imvamisa engaphansi kuka-10Pa), amakristalu eqhwa angena ngokuqondile kumhwamuko, asuse ngaphezu kuka-90% wento encibilikayo.
Ukomisa Kwesibili (Ukukhipha I-Desorption):Ukwenyuka kwezinga lokushisa okumaphakathi (20-40°C) kusiza ukuncibilika ngokuphelele kwamanzi abophekile, okuholela ekutheni kube nomswakama wokugcina ongu-1% -5%.
Le nqubo iqeda ukulimala kwezinga lokushisa eliphezulu ezintweni ezingezwani nokushisa, ilondoloze ukwakheka kwamangqamuzana amaprotheni, ama-enzyme, namavithamini. Ukwengeza, kwakha isakhiwo esinezimbotshana esiza ukubuyisela amanzi emanzini kalula noma ukusetshenziswa okuqondile.
Izinzuzo Eziyinhloko Zokomisa Iqhwa Laselabhorethri
Uma kuqhathaniswa nemishini yezinga lezimboni, okomisa iqhwa elabhorethri kunikeza ukulawula okunembayo okuphakeme kanye nezinzuzo zokucubungula amaqoqo amancane:
Ukulawula Izinga lokushisa Okunembile:Imodeli yomshini wokomisa "YOKUBILI".I-ZLGJ-12, isibonelo, isebenzisa ubuchwepheshe bokupholisa i-compressor obungenisiwe, obufinyelela amazinga okushisa ogibe aphansi -80°C ukuqinisekisa ukuqandisa okusheshayo.
I-Intelligent Vacuum Management:Izinzwa ezinemba okuphezulu ngokuqhubekayo ziqapha amazinga we-vacuum (≤5Pa), ngezindlela zokuvikela ezakhelwe ngaphakathi ukuvimbela ukugcinwa kwe-solvent.
I-Gradient Heating for Concentration:Ifakwe ukushisisa kweshalofu okuhlelekayo (okufana nobuchwepheshe bokulawula "KOKUBILI" okomisa okomisa kwe-PLD), lawa masistimu avumela amajika okushisa afanelanisiwe wezinto ezihlukene, okwandisa ukugxila.
Isibonelo, ocwaningweni lwaselabhorethri yebhayoloji olubandakanya ukomiswa kwe-antibody, izindlela ezivamile zokuhwamuka ziholele ekuhlanganisweni kwamaprotheni kanye nokwenza kungasebenzi. Ngokuphambene, ukumisa iqhwa emazingeni okushisa aphansi kulondoloza ngaphezu kwama-95% womsebenzi wamasosha omzimba, nomphumela wempushana uzinze kakhudlwana ekugcinweni kwesikhathi eside.
Njengenkampani esebenza ngemishini yokumisa iqhwa yasekhaya iminyaka engu-17, okomisa okomisa "KOKUBILI" kuthuthukise ukusebenza kahle kokususa i-solvent ngokuqamba okusha kwezobuchwepheshe.
1. Uhlelo Olugcwele Lokulandelelwa Kwedatha
Isomisi esiqandisa ilabhorethri ethi "BOTH" ifakwe isikrini esithintwayo esinemibala kanye nemojula yokugcina idatha (ekwazi ukugcina amarekhodi angafika ku-100,000). Inikeza amajika e-vacuum esikhathi sangempela okushisa, okuvumela abacwaningi ukuthi banqume ngokunembile isiphetho se-solvent sublimation, ukuvimbela ukoma ngokweqile noma izinkinga ze-solvent ezisele.
2. Izindlela Eziningi Zokuvikela Ukuphepha
I-automatic vacuum pump lockout uma izinga lokushisa logibe lingaphezu kuka -50°C ukuvimbela umonakalo wokubuyela emuva.
Ama-alamu omsindo nokukhanya asebenza ngokuzenzakalelayo uma kwenzeka kuba ne-vacuum engasebenzi noma ukushintshashintsha kwezinga lokushisa okungavamile.
Ukunikezwa kwamandla okuzithandela kwe-UPS kugcina ukusebenza kwesistimu yokulawula imizuzu engama-20 phakathi nokuphela kukagesi, okuqinisekisa ukuqhubeka kokuhlolwa.
3. Ukunwetshwa kwe-Modular Function
Ngesistimu yomjovo wegesi wokucindezela kabusha ozenzakalelayo, amagesi angasebenzi njenge-nitrogen angangeniswa egumbini lokomisa ukuze kuvinjelwe ukusabela kwe-oxidation phakathi nokuhlangana kwezinyibilikisi ezizwela umoya-mpilo (isb, i-ethanol). Igumbi, elenziwe ngensimbi engagqwali ehlanzekile enomklamo wesicupho esingenakhoyili, liqeda izingozi zokungcola.
Izikomisi zokuqandisa zaselabhorethri zishintshile zisuka kumathuluzi alula okukhipha amanzi emzimbeni zaba yizinkundla eziyinkimbinkimbi zokulawula inqubo. "OKUBILI"ZLGJuchungechunge, ngomklamo wayo ohlakaniphile kanye ne-modular, ayithuthukisi nje kuphela ukusebenza kahle kokususwa kwe-solvent kodwa futhi yenza ukuqapha kwesikhathi sangempela kanye nokwenza kahle kwenqubo yokuhlushwa. Kubacwaningi ababeka kuqala ukunemba kokuhlolwa kanye nemiphumela ezinzile, lawa madivayisi aba "umsizi wenqubo ojwayelekile" obaluleke kakhulu kulabhorethri.
Isikhathi sokuthumela: Mar-13-2025
