Emasimini ama-biopharmaceuticals kanye nocwaningo lwesayensi, ukukhishwa kwe-solvent kanye nokugxilisa izinto ezibonakalayo kuyizinyathelo ezibalulekile kuzo zombili izinqubo zokuhlola nezokukhiqiza. Izindlela zendabuko ezifana nokuhwamuka kanye ne-centrifugugation zivame ukuhlushwa ukungasebenzi kahle, ukulahleka kwezithako ezisebenzayo, nokususwa kwe-solvent okungaphelele. I-Laboratory Freeze Drychers, ngezinzuzo zazo ezihlukile zokushisa okuphansi kanye nengcindezi ephansi, ziveze njengamathuluzi asebenza kahle kwalezi zinqubo. Phakathi kwazo,"Kokubili" Ama-Freeze Workebaphambili kokuthuthuka lobu buchwepheshe.
Isayensi ngemuva kokumiswa kweqhwa: ukopha okushisa okuphansi
A I-Laborator Freeze Dryerifinyelela ukususwa kwe-solvent kanye nokugxilisa izinto ezibonakalayo ngokusebenzisa izigaba ezintathu ezibalulekile:
Isiteji Esibandayo:Izinto eziqukethe izixazululo zidla ngokushesha emazingeni okushisa asukela ku-40 ° C kuya ku -80 ° C, akha amakristalu aqinile weqhwa.
Ukomisa Okuyisisekelo (Okungaphezulu):Ngaphansi kwemvelo ye-vacuum (ngokujwayelekile ngaphansi kwe-10PA), amakristalu eqhwa afaka ngokuqondile ku-water vapor, asuse ngaphezu kwama-90% we-solvent.
Ukomisa okwesibili (incorption):Ukwanda kokushisa okulindwe (40-40 ° C) kusiza ukufona ngokuphelele kwamanzi aboshwe, okuholela ekuqukethwe komswakama kokugcina kwe-1% -5%.
Le nqubo isusa ukulimala okushisa kakhulu ezintweni ezibucayi okushisa, kulondolozwa ukwakheka kwamaphrotheni kwamaprotheni, ama-enzyme, namavithamini. Ngokwengeziwe, kwakha isakhiwo se-porous esisiza ukuvuselelwa okulula noma okuqondile.
Izinzuzo ezisemqoka ze-Laboratory Freezer Dreaters
Uma kuqhathaniswa nemishini yezimboni ezinezimboni, owomisa i-laboratory freezers anikezela ngokulawula okuphezulu kokunemba kanye nezinzuzo zokucubungula ezincane:
Ukulawulwa kokushisa okuqondile:Imodeli ethi "Kokubili" Freezerze Dryer DryerZlgj-12Yebo, ngokwesibonelo, kusebenzisa ubuchwepheshe bokupholisa abathengisayo ongenisiwe, ukufika emazingeni okushisa okuphonsa aphansi njengoba -80° C ukuqinisekisa ukubanda okusheshayo.
Ukuphathwa kwe-vacuum ehlakaniphile:Izinzwa eziphezulu zokuqondisa okunengqondo ngokuqhubekayo zibheka amazinga we-vacuum (≤5pa), ngezindlela zokuvikela ezakhelwe ngaphakathi ukuvikela ukugcinwa kwe-solvent.
Ukufudumala okuphezulu kokuhlushwa:Ihlotshiswe nge-pluefting ehlelekile (enjenge-control control control yokulawula "ye-" Freezer Dryer Pld), lezi zinhlelo zivumela ama-curve okushisa afanelekile wezinto ezahlukahlukene, ukuthuthukisa okuhlushwa.
Isibonelo, ekuhlolweni kwelabhoratri okubandakanya ama-antibody-yomiswa, izindlela zokuhwamuka zendabuko ziholele ekuhlanganiseni kwamaprotheni kanye nokwenza iphutha. Ngokuphambene nalokho, ukomisa - ukumiswa kwamazinga okushisa okuphansi okugcinwe ngaphezulu kwama-95% womsebenzi we-antibody, nge-powder ephumayo ibe izinzile kakhulu kwisitoreji sesikhathi eside.
Njengenkampani egxile emishini yokumisa yasendlini yezeminyaka yeminyaka eyi-17, "bobabili" ama-freeze dreamers athuthukise ukusebenza kahle kwezolvent ngokuqhubeka kwezobuchwepheshe.
1. Inqubo ephelele yokuhlola idatha
I- "" Yobubili "Laba Laboratorary Freezerry Dryer lifakwe isikrini sokuthinta sombala kanye nemodyuli yokugcina idatha (ekwazi ukugcina amarekhodi afinyelela kuma-100,000). Inikeza amazinga okushisa wesikhathi sangempela-vacuum curve, enika abacwaningi ukuthi bakwazi ukuthola kahle ukuphela kwe-solvent sublimation, ukuvimba izingqinamba zomoya noma ezisalayo zomoya.
2. Izindlela zokuvikelwa kokuphepha eziningi
I-othomathikhi ye-vacuum pump Lovilkout uma izinga lokushisa lesigibe lingaphezulu -50 ° C ukuvikela ukulimala emuva.
Ama-alamu anomsindo futhi akhanyayo ngokusebenza okuzenzakalelayo kokuvikela uma kwenzeka ukwehluleka kwe-vacuum noma ukuguquguquka kwezinga lokushisa okungajwayelekile.
Ukuhlinzekwa kwamandla okukhethwa kukho okukhethwa kukho okulawula Ukusebenza kokulawula imizuzu engama-20 ngesikhathi sokuphuma kwamandla, kuqinisekiswe ukuqhubeka kokuhlolwa.
3. Ukunwetshwa komsebenzi okuguquguqukayo
Ngohlelo lokuhlobisa okuzenzakalelayo lwe-othomathikhi yokuphinda usebenzise kabusha, amagesi afana ne-nitrogen angangeniswa egumbini lokumisa ukuvimba ukusabela kwe-oxidation ngesikhathi sokuhlangana okubucayi komoya-mpilo (isib. Ethanol). IChamber, eyenziwe ngensimbi engenacala nge-COIN-Free Drap Design, iqeda ubungozi bokungcola.
I-Laboratory Freeze Drime ivele kusuka kumadivayisi alula wamanzi kumapulatifomu wenqubo eyinkimbinkimbi. "Bobabili"I-ZLGJ-uhume, ngokusebenzisa design yayo ehlakaniphile futhi eguqukayo, akugcini nje ngokuthuthukisa ukusebenza kahle kwe-solvent ukususa kepha futhi kunika amandla ukuqapha kwesikhathi sangempela nokwenza kahle kwenqubo yokuhlushwa. Kwabaphenyi ababeka phambili imiphumela yokuhlola yokuhlola nemiphumela ezinzile, la madivayisi aqala "umsizi wenqubo ojwayelekile" ojwayelekile "ezindaweni zokucwaninga.
Isikhathi sePosi: Mar-13-2025
